All-in-one model reconstructs complex liver architecture Dresden researchers develop next-generation organoid model to better understand liver disease Date: May 30, 2025 Source: Max Planck ...

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Liver disease modelling: This liver model reconstructs the liver periportal region architecture, is able to model aspects of cholestatic liver injury and biliary fibrosis, and can show how different ...

New tissue-derived organoid model: A next-generation organoid model, composed of three liver cell types – adult hepatocytes, cholangiocytes, and liver mesenchymal cells – reconstructs ...

Existing tissue-derived liver organoid models consist of only one cell type and fail to replicate the complex cellular composition and tissue architecture, such as the liver periportal region.