Liver fibrosis is the build up of scar tissue in the liver when it tries to heal itself. Symptoms may include fatigue, swelling, and weight loss.

Not only is hepatic fibrosis reversible, but it is also increasingly clear that cirrhosis ... mechanisms, and will likely lead to new therapies for fibrotic diseases of many organs, including liver.

Increasing evidence highlights a bidirectional relationship between circadian disruption and hepatic pathophysiology, suggesting liver disease is both a consequence and a driver of circadian ...

Over time, fibrosis can impair liver function and may lead to cirrhosis or even liver cancer. Those at risk include individuals with chronic viral hepatitis, obesity, diabetes and excessive ...

Hepatic fibrosis is the common result of injury to the liver from a variety of damaging mechanisms ... whereas in cirrhosis the levels are generally >12–14 kPa (Rockey 2008).

A comprehensive proteomic map of liver fibrosis progression and healing in two mouse models identifies etiology-specific extracellular matrix components, laying the foundation for targeted ...

The liver is a vital organ, crucial to digestion, metabolism and the elimination of toxins. It has a unique ability, regeneration, which allows it to replace liver cells damaged by the very toxins ...

For the latter, advanced fibrosis can progress to liver cirrhosis, the later and irreversible stage of liver disease, where secondary complications such as ascites, an accumulation of fluid in the ...

Data from patients across 3 different randomized controlled trials showed improvements in both adiponectin and PRO-C3, primary end points in the trials.

Liver TET1 was found to promote metabolic dysfunction-associated steatotic liver disease (MASLD) by regulating CD36 expression, suggesting TET1 as a therapeutic target for MASLD treatment. TET1 ...

As there are no effective drugs to treat cirrhosis, suppressing the activation of the stellate cells is considered as a way ...