At the heart of the kinetochore is a specialized nucleosome that contains centromere protein (CENP)-A, a histone H3 homologue. Several inner kinetochore components (cyan and purple ovals ...

The centromere consists of centromeric DNA and a multiprotein complex, the kinetochore. The kinetochore ensures the correct distribution of chromosomes between the two daughter cells and ...

Today, the number of known CENP proteins is about 20, and that number may increase as our understanding of the kinetochore grows. The primary function of the centromere is to provide the ...

Our studies showed that selfish centromeres drive by amplifying the kinetochore pathway to recruit destabilizers, thus increasing functional differences. In contrast, heterochromatin is symmetric ...

During mitosis, spindle microtubules capture the kinetochore formed in the centromere. After mitosis, chromosomes are divided into daughter cells. Disclaimer: AAAS and EurekAlert! are not ...