For input variable screening purposes, it can be found that some input variables of this function have a very high effect on the output, compared to other input variables. As Welch et al. (1992) point ...

Here we explore how modular domains can be used to build an ultrasensitive switch—a nonlinear input/output function that is central to many complex biological behaviors. By systematically ...

This function's a-coefficients are chosen so that 5 of the input variables contribute significantly to the output variance, 5 have a much smaller effect, and the remaining 5 have almost no effect on ...