Here we explore how modular domains can be used to build an ultrasensitive switch—a nonlinear input/output function that is central to many complex biological behaviors. By systematically ...

For input variable screening purposes, it can be found that some input variables of this function have a very high effect on the output, compared to other input variables. As Welch et al. (1992) point ...

This function's a-coefficients are chosen so that 5 of the input variables contribute significantly to the output variance, 5 have a much smaller effect, and the remaining 5 have almost no effect on ...