Sickle Cell Disease is a complex and debilitating genetic blood disorder that primarily affects people of African, Mediterranean, Middle Eastern, and Indian ancestry.It is caused by a mutation in the ...

Sickle cell anaemia is caused by a mutation in the HBB gene, which provides instructions for making the beta-globin subunit of haemoglobin. The disorder follows an autosomal recessive inheritance ...

Beti-cel uses a self-inactivating lentiviral vector to deliver a functional copy of the HBB gene into patients' blood stem cells, allowing the cells to produce normal beta-globin protein and to ...