If Excel crashes or freezes when running macro, without saving, when opening file from network, copy-pasting, deleting rows, then see this post.

If Excel stops responding when switching between worksheets, follow the suggestions in this post to resolve the problem without losing data.

Hope Excel file launches without any issue but if in case not try disabling the “COM Add-ins”, “Actions” and “XML Expansion Packs”. Hope doing this fixes the Excel file slow to respond.