This marked the second time this season that San Francisco (2-3) blew a double-digit lead in the fourth quarter to a division rival, having done it in Week 3 against the Los Angeles Rams.

Chad Ryland drilled a 35-yard field goal to give the Cardinals a 24-23 lead. Purdy had one last chance to drive down the field with just over 90 seconds remaining. However, the Cardinals were able to tip a pass from Purdy and intercept the ball to essentially end the game.

After the 49ers evened their record at 2-2 by beating the Patriots, the next step is to stack wins on top of each other, which the Niners have a chance of doing Sunday against the Arizona Cardinals.