Compare the 2025 Mercedes-Benz S-Class and 2025 Mercedes-Benz E-Class. Uncover the best in specs, performance, and innovation for your next ride.

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The 2022 Mercedes-Benz S-Class Base featured in the comparison below has an overall data-driven rating of 3.00 and the 2022 Mercedes-Benz E-Class Base has an overall data-driven rating of 3.50.