In addition, multiple microtubules appear to insert into the kinetochore, which is positioned on the side of the chromosome facing the spindle pole to which the chromosome will be drawn during ...

The length of these kinetochore-attached microtubules then decreases during mitosis, pulling sister chromatids to opposite poles of the spindle. Other spindle fibers do not attach to chromosomes ...

Specialized sites on the chromosomes called kinetochores attach to spindle microtubules, and these kinetochore-microtubule attachments are necessary for proper chromosome segregation. Problems in ...

Our studies showed that selfish centromeres drive by amplifying the kinetochore pathway to recruit destabilizers, thus increasing functional differences. In contrast, heterochromatin is symmetric ...

In model organisms like yeast, it has been shown that kinetochore-microtubule interaction is disrupted during chromosome ...

These findings emphasize the importance of the N-terminal domain of CENP-A/Cse4 and interactions with a chaperone protein and another kinetochore complex plus a kinase to stabilize assembly of ...

Chromosome transmission errors may also sensitize tumor cells ... rather than in strict coordination with outer kinetochore assembly (Maciejowski et al., 2010). Furthermore, our analog-sensitive cell ...

Prometaphase: During this phase, the spindle fibers formed between the centrosomes and the newly made microtubules attach to the kinetochore of each chromosome. Encourage students to modify their ...