whereas the 2.2-Å structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided ...

They measured the levels of the proteins C3, C4, CH50, and C3D, which are biomarkers of the complement system. To assess how these complement biomarkers changed over time, the researchers ...

The C3d tags the neuron for ... neurons can be still salvaged. Complement is deposited and microglia attack neurons that could otherwise recover their function. We found that B4Crry prevented ...

We are studying the role of the complement system in kidneys and brains during health and disease. Traditionally, major complement proteins were shown to be generated by the liver and are functional ...

These effects, which are mediated by the CR2-C3d interactions on B cells and FDCs, are collectively referred to as the “molecular adjuvant” effects of complement and this is important in ...

Researchers at the Medical University of South Carolina treated mice with a compound that curbed this response locally, improving their recovery without affecting immune function in the rest of ...

Abstracts are available here. ADX-097, Q32 Bio's lead product candidate from its tissue-targeted complement inhibitor platform, is a humanized anti-C3d mAb fusion protein being evaluated for the ...

tubular atrophy and evidence of complement involvement. Diagnosed with IgA vasculitis, she developed rapidly worsening kidney function with highly elevated creatinine levels, hypertension ...