Oquawka is a village and the county seat of Henderson County, Illinois, United States. The population was 1,134 at the 2020 census. Oquawka is part of the Burlington micropolitan area. According to the 2021 census gazetteer files, Oquawka has a total area of 1.86 square miles, of which 1.47 square miles is land and 0.39 square miles is water.