The role of ROS in tumor infiltrating immune cells and cancer ...
WEBFeb 1, 2024 · NOX2 derived ROS facilitated the metastasis of melanoma through downregulation of NK cell functionality due to ROS-mediated damage. Furthermore, NK cells without NOX2 secreted significantly more IFN-γ implying that compromised cytolytic capacity was a consequence of ROS production mediated by NOX2.
Neutrophil-derived reactive oxygen species promote tumor
WEBJul 13, 2021 · These results suggest that IL-1β promote tumor colonization as a downstream effect of ROS. NK cells may play a role in IL-1β signaling, but not critically in regulating the Ncf1 effect.
Reactive Oxygen Species and Antitumor Immunity—From …
WEBJul 1, 2020 · In addition, ROS may regulate the expression of co-signaling receptors for T cells (i.e., CD80 costimulatory molecule and PD-L1 coinhibitory molecule) and of NK cell ligands (i.e., MHC class I chain-related protein A and B MICA and MICB).
Dual Role of Reactive Oxygen Species and their Application in …
WEBJul 25, 2021 · The upregulation of ROS inhibits T cells and NK cells, recruits macrophages, and induces M2 macrophage polarization. The overproduction of ROS attenuates the phosphorylation of eIF2B, thereby downregulating NKG2D/NKG2Dls and suppressing NK cell-mediated ADCC activity.
Metabolism of Natural Killer Cells and Other Innate Lymphoid Cells
WEBAug 28, 2020 · The proliferative burst of NK cells leads to mitochondrial depolarization and accumulation of mitochondrial-associated reactive oxygen species (ROS).
ROS fine-tunes the function and fate of immune cells
WEBJun 1, 2023 · The reduction of ROS benefits to NK cell survival and function. In the tumor microenvironment (TME), exorbitant ROS levels block NK cell survival and function. NK cell activation and functional expression promotions are decided by the balance between inhibition and stimulation of surface receptors.
Reactive oxygen species in immune cells: A new antitumor target
WEBJan 1, 2021 · In this review, we discuss the role of ROS in different immune cells, including myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), tumor-associated macrophages (TAMs), cytotoxic T lymphocytes (CTLs), natural killer cells (NKs), and dendritic cells (DCs).
Dual roles of neutrophils in metastatic colonization are governed …
WEBSep 1, 2020 · In this study, using mouse models of breast cancer, we demonstrate that the metastasis-modulating effects of neutrophils are dictated by the status of host natural killer (NK) cells.
Tumor-associated NK cells drive MDSC-mediated tumor immune …
WEBMay 15, 2024 · Apart from their killer identity, natural killer (NK) cells have integral roles in shaping the tumor microenvironment. Through immune gene deconvolution, the present study revealed an interplay bet...
NK cells in the tumor microenvironment and thioredoxin activity
WEBSep 14, 2020 · NK cells are responsible for defense against viral infections and cancer. Although activated NK cells are armed to combat tumors, the tumor microenvironment (TME) contains ROS, which suppress NK cell antitumor activity.