Pyrazole - Wikipedia
WEBPyrazole is an organic compoundwith the formula (CH) 3 N 2 H. It is a heterocycle characterized as an azole with a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms, which are in ortho-substitution. Pyrazole itself has few applications but many substituted pyrazoles are of commercial interest.
Current status of pyrazole and its biological activities
WEBPyrazoles are reported to possess a wide range of biological activities in literature such as anti-microbial, anti-fungal, anti-tubercular, anti-inflammatory, anti-convulsant, anticancer, anti-viral, angiotensin converting enzyme (ACE) inhibitory, neuroprotective, cholecystokinin-1 receptor antagonist, and estrogen receptor (ER) ligand activity,...
Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
WEBJun 5, 2021 · Commercially available pyrazole moiety examples as potent COX-2 inhibitors are Celecoxib [15], Ramifenazone [16], Lonazolac (NSAID) [17] and Rimonabant [18] (Figure 1). The search for safer NSAIDs continues with the failure of anticipated “ideal” anti-inflammatory drugs, the coxibs, on long term usage [19].
Pyrazole: Uses, Interactions, Mechanism of Action - DrugBank …
WEBJun 13, 2005 · Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter.
Synthesis and Pharmacological Activities of Pyrazole Derivatives: A ...
WEBJan 12, 2018 · A series of pyrazole-3-carboxylic acid and pyrazole-3,4-dicarboxylic acid derivatives were synthesized and evaluated for their antibacterial and antifungal activities against five bacterial and five fungal pathogens.
Pyrazoles - DrugBank Online
WEBAn NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. Entrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults.
Pyrazole: An Important Core in Many Marketed and Clinical Drugs …
WEBThis review summarizes recent advances in the use of the pyrazole scaffold and provides pharmacologists with a road map for developing novel preclinical and clinical pyrazole-based drugs.
Pyrazole - an overview | ScienceDirect Topics
WEBExamples of commercial substances containing a pyrazole ring.
Pyrazole - an overview | ScienceDirect Topics
WEBPyrazole is a five-membered nitrogen heterocyclic, can be found in a big number of pharmacological active agents. There has been growing interest in the development of bioactive molecules carrying the heterocyclic pyrazole.
Recently reported biological activities of pyrazole compounds
WEBNov 1, 2017 · Pyrazole derivatives have exhibited a broad spectrum of biological activities, and approved pyrazole-containing drugs include celecoxib, antipyrine, phenylbutazone, rimonabant, and dipyrone. Many research groups have synthesized and evaluated pyrazoles against several biological agents.